This is the upgraded (2.0) version of H++. The main changes relative to the previous release (1.0) are summarized below

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1. Ability to automatically process non-protein ligands has been added.

2. Ability to automatically process DNA and RNA, whether as a ligand or as a stand-alone structure. When no titratable site are found, the PQR (and AMBER topology/coordinate) files are still generated.

3. Registered users now have access to all runs, including the failed ones. A master log file containing all major warning/error messages is now available.

4. Total charge at the user specified pH is now reported.

5. Separate output option for AMBER explicit solvent box (no box by default)i has been added.

6. Total charge is now reported on the titration curve.

7. Several minor bugs fixed.